An interim analysis of data from Phase III trials published in the Lancet today shows that the ChAdOx1 nCoV-2019 vaccine, developed by University of Oxford and AstraZeneca, administered in two doses, was highly effective. Guy’s and St Thomas’ NHS Foundation Trust is a participating centre in this trial.
The vaccine was 90% effective if administered at a half dose and then at a full dose, or 62% effective if administered in two full doses. The data also showed lower rates of asymptomatic infection in the people who had received the half dose followed by a full dose regimen, which suggests that the vaccine could help to prevent transmission of the virus. Additionally, there were no hospitalised or severe cases of COVID-19 in anyone who received the vaccine.
The research to date has been made possible thanks to the 24,000 volunteers who took part in the trial, and the hard work of the talented teams who delivered the research around the world.
Dr Anna Goodman, consultant in infectious diseases, who is the Principal Investigator for the trial at Guy’s and St Thomas’, said: “Over 400 research, clinical and non-clinical staff supported the delivery of the trial at Guy’s and St Thomas’. We are extremely proud and grateful for every single contribution. It is only because of the selfless commitment of the trial participants and dedication of teams just like ours around the world that this work to help halt the progress of the pandemic has been possible. A sincere thank you to each and every one of you.”
Those who supported the trial at Guy’s and St Thomas’ include:
Participants
All of the 492 participants in the trial at Guy’s and St Thomas’.
Teams
R&D governance team
R&D admin
R&D communications team
Guy’s and St Thomas’ communications team
Essentia support
Procurement team
Pharmacy
The Clinical Research Facility team
Staff Bank
Nursing and midwife staffing tactical
ICU matrons
HIV team
Dental team
Rare Disease Centre team
COVID-19 research team
COVID-19 research reception team
Charitable organisations
The XP support group (https://xpsupportgroup.org.uk/)
DEBRA (https://www.debra.org.uk/)
Guy’s and St Thomas’ Charity (www.gsttcharity.org.uk)
Individuals
Abayomi Fatola
Abigail Burgess
Aidan Haslam
Alexander Emery
Alfie Balston
AliAsad Hashtroudi
Alice Lewin
Alice Sharp
Alina Botgros
Alistair Weir
Alyce Sheedy
Amrit Visvanathan
Amy Day
Amy Holton
Andrea Mazzella
Andreas Ziakas
Andrew Ghobrial
Andrii Boguslavskyi
Anele Waters
Ania Rainbird
Anna Barnard
Anna Black
Anna Perman
Anne Collett
Anoosha Gadiraju
Antonia Lynch
Anya Vlassoff
Araminta Roper
Arthika Surendran
Ashley Sartini
Aysan Koray
Balathas Thirugnanabalan
Beth Jackson
Blair Merrick
Carolyn Hemsley
Cassandra Fairhead
Cassie Fairhead
Charles Wolfe
Charlotte Faint
Charlotte Gibbs
Cherry Paice
Chinenye Orji
Clair Harris
Claire Harrison
Claire O’Neill
Claire Singh
Damir Rafi
Dan Furmedge
Daniel Curley
David Lammas
David Oppenheim
David Wood
Dawn Beaumont-Jewell
Deborah Mundle
Deepali Patel
Deirdre Wallace
Dharsha Shivapatham
Dhruv Sarma
Dionne Gill
Elizabeth Pillay
Elizabeth White
Elliot Byford
Elysia James
Eme Chan
Emilia Gnat
Emma Wayman
Estratios Gerakopoulos
Eunice Jeffs
Eva Klamerus
Fahim Ahmed
Fardusa Hassan
Federica Francia
Federico Borchini
Fiona Hibberts
Franca Morselli
Frances Doyle
Gabriel Lee
George Nintos
Geraldine OHara
Gerry Trillana
Gill Arbane
Gladys Monde
Hayley Tarft
Hazel Honeywell
Hemawtee Sreeneebus
Henry Fok
Hilary Thompson
Holly Lovell
Ian Abbs
Ike Obi
Ilknur Shevket
Imogen Peplow
Jack Kingdon
Jackie Pullen
Jakob Jeriha
James Spicer
James Williams
Jasper Vink
Jayshireen Singh
Jeff Brazel
Jessamine Hunt
JinSun Yoo
Jo Furley
Joan Fleetwood-Joyce
Joan Nanan
Joanne Palmer-Joyce
Johannes Driessen
Jonathan Essex
Joseph Parsons
Joshua Au Yeung
Julie Fox
Julie John
Karen Bisnauthsing
Karen Walker
Karen Wilson
Karina Mahiouz
Kate Blake
Katherine Blackstone
Krzystof Rutkowski
Laura Bremner
Lauren Arnold
Lauren Martinez
Leanna Brace
Linda Gomm
Louise Griffiths
Luca Scott
Luciana Sowole
Lucy Storey
Lydia Gojke
Magdalena Martinez-Queipo
Mai Worthington
Maria Flaquer
Martinez Castrillo
Matea Deliu
Melanie Haines
Moncy Matthew
Mguni Nhlanhla
Mijan Miah
Mike Lyne
Naomi Hare
Natalie Grey
Natalie Page
Natalie Palmer
Natasha Ajraam
Neil Morton
Nick Hart
Nick Price
Nicola McCutcheon
Nicola Varatharajah
Nieves Velazquez
Noelia Pitrelli
Nuria Martinez-Alier
Olanike Okolo
Oluseyi Daropale
Olympia Tsilochirustou
Parizade Raymode
Paul Burdett
Paul Dargan
Paula Darroch
Peter Bennett
Phil Chowienczyk
Rachael Morris-Jones
Rahel Werku
Rajesh Bhooban
Ramesh Thurairaja
Raquel Ihekwoaba
Rashida Pramanik
Rebekah Roberts
Rezaur Rahman
Rhys Brown
Ria Brunton
Richard Love
Rishi Iyer
Rizwana Dakri
Robert Cormack
Robert Sanarky
Roni Cummings
Roser Guiteras
Sahnaj Sultana
Sally Walker
Samantha Broadhead
Samantha Buckner
Samantha Salaver
Sara Jane Lyons
Sarah Betts
Sarah Keegan
Sarah Rodrigues
Sarah Ruiz
Servious Dube
Sharon Whelan
Shaun Cochrane
Shelley Mieres
Shevanti Sandrasagra
Simbiso Maswera
Simon Goldenberg
Sinead O’Dwyer
Sonia Serrano
Stephen Till
Sue Cox
Tammy Davey
Teresa Crowley
Teresa Solano
Tess Cheetham
Tharnitha Vasavan
Thi DieuVu
Thurkka Rajeswaran
Tiago Soares
Tim Borrie
Tom Williams
Vaishali Vyas
Vanessa Parker
William Wells
Yemi Adelaja
Zandile Khumalo
Zareen Bheekhun
Zoe Vowles
